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Published (2008-2012)

  • Paper                              Patents

C. Yoshihara, K. Hamada, M. Kuroda, Y. Koyama, Oncolytic plasmid: A novel strategy for tumor immuno-gene therapy, Oncol Lett, 3, 387–390, 2012

K. Hamada, C. Yoshihara, T. Ito, K. Tani, M. Tagawa, N. Sakuragawa, H. Itoh, Y. Koyama, Antitumor effect of chondroitin sulfate-coated ternary GMCSF plasmid complex for ovarian cancer, The Journal of Gene Medicine, 14, 120-127, 2012,

K. Hagiwara, M. Nakata, Y. Koyama, T. Sato, The effects of coating pDNA/chitosan complexes with chondroitin sulfate on physicochemical characteristics and cell transfection, Biomaterials, 33, 7251–7260, 2012

T. Ito, Y. Koyama, M. Otsuka, DNA complex-releasing system by injectable self-setting apatite cement, The Journal of Gene Medicine, 14, 251-261, 2012

T. Ito, C. Yoshihara, K. Hamada, Y. Koyama, DNA/polyethyleneimine/hyaluronic acid small complex particles and tumor suppression in mice, Biomaterials, 31, 2912-2918, 2010,

C. Yoshihara, C. Yang Shew, T. Ito, Y. Koyama, Loosening of DNA/polycation Complexes by Synthetic Polyampholyte to Improve the Transcription Efficiency: Effect of Charge Balance in the polyampholyte, Biophysical Journal, 98, 1257-1266, 2010

C. Yoshihara, K. Hamada, Y. Koyama, Preparation of a novel adenovirus formulation with artificial envelope of multilayer polymer-coatings: Therapeutic effect on metastatic ovarian cancer, Oncology Reports, 23, 733-738, 2010

T. Ito, Y. Koyama, M. Otsuka, Analysis of the surface structure of DNA/polycation/hyaluronic acid ternary complex by Raman microscopy, Journal of Pharmaceutical and Biomedical Analysis, 51, 268-272, 2010

K. Hamada, T. Zhang, J. Desaki, K. Nakashiro, H. Itoh, K. Tani, Y. Koyama, H. Hamakawa, Carrier cell-mediated cell lysis of squamous cell carcinoma cells by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus, The Journal of Gene Medicine, 12, 545–554, 2010

T. Ito, N. Iida-Tanaka, Y. Koyama, Efficient in vivo Gene Transfection by Stable DNA/PEI Complexes Coated by Hyaluronic Acid, Journal of Drug Targeting, 16, 276-281, 2008

M. Sakae, T. Ito, C. Yoshihara, N. Iida-Tanaka, H. Yanagie, M. Eriguchi, Y. Koyama, Highly efficient in vivo gene transfection by plasmid/PEI complexes coated by anionic PEG derivatives bearing carboxyl groups and RGD peptide, Biomedicine & Pharmacotherapy, 62, 448-453, 2008

M. Hashimoto, Y. Koyama, T. Sato, In vitro Gene Delivery by pDNA/Chitosan Complexes Coated with Anionic PEG Derivatives That Have a Sugar Side Chain, Chem Lett., 37, 266-267, 2008

"Haidoro geru keiseizai"
Japanese patent application No. 2012-233453

"Shinki na fukugoutai, sorewo gan-yu suru iyakuhin oyobi gan no chiryouhou"
Japanese patent application No. 2011-201136

"Shinki na bekuta, sorewo gan-yu suru iyakuhin oyobi gan no chiryouhou"
Japanese patent application No. 2010-20766

"Complex of virus, therapeutic agent comprising same, and therapeutic method"
Established in China
PCT/JP2010/058236 2010.4.28

"Idenshi Chiryouzai"
Japanese patent application No. 2010-173990

"Kakusan Fukugoutai Johou Tantai"
Japanese Published Unexamined Application No. 2011-012041


Established in China